Hemophilia is as old as the humanity, but it has never had a direct influence on the affairs of a nation. This was until the disease mysteriously appeared in descendants of Queen Victoria, “the grandmother of Europe”, successively touching the heirs to the throne of Russia and Spain. In particular Alix of Hesse and Victoria Eugenie of Battenberg, granddaughters of the English queen (and also second cousins through German kinship), who had to face not only a personal and human drama, but a dynastic tragedy with various reflections, especially for the first, in the vicissitudes policies of their adoptive countries.

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